Seroatlas · Human Serome Atlas

RPS14

Small ribosomal subunit protein uS11

Also known as: EMTB, RS14_HUMAN, S14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62263
Gene
RPS14
Ensembl
ENSG00000164587
Chromosome
5
Canonical length
151 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>P62263|RPS14
     1  MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM
    61  KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT GGNRTKTPGP GAQSALRALA
   121  RSGMKIGRIE DVTPIPSDST RRKGGRRGRR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
2,301 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 2,301 nTPM
  • ovary: 2,268 nTPM
  • skin: 2,078 nTPM
  • bone marrow: 1,772 nTPM
  • cervix: 1,504 nTPM
  • breast: 1,484 nTPM

Single-cell type

  • esophageal suprabasal cells: 13,115 nCPM
  • esophageal basal cells: 11,351 nCPM
  • extravillous trophoblasts: 10,952 nCPM
  • decidual stromal cells: 10,309 nCPM
  • suprabasal keratinocytes: 10,189 nCPM
  • migrating cytotrophoblasts: 9,742 nCPM

Immune cell

  • total PBMC: 34,362 nTPM
  • naive CD4 T-cell: 16,840 nTPM
  • memory B-cell: 14,586 nTPM
  • naive B-cell: 12,534 nTPM
  • naive CD8 T-cell: 11,742 nTPM
  • memory CD4 T-cell: 11,414 nTPM

Brain region

  • spinal cord: 504 nTPM
  • white matter: 461 nTPM
  • thalamus: 458 nTPM
  • medulla oblongata: 440 nTPM
  • hypothalamus: 427 nTPM
  • basal ganglia: 421 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.9
gnomAD missense Z
2.52
DepMap mean gene effect
-2.15
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS14 as an antibody target. Whether an autoantibody or antibody against RPS14 could matter depends on whether native RPS14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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