Seroatlas · Human Serome Atlas

RPL37A

Large ribosomal subunit protein eL43

Also known as: L37A, RL37A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61513
Gene
RPL37A
Ensembl
ENSG00000197756
Chromosome
2
Canonical length
92 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P61513|RPL37A
     1  MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR AVGIWHCGSC
    61  MKTVAGGAWT YNTTSAVTVK SAIRRLKELK DQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL37A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
5,410 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 5,410 nTPM
  • skeletal muscle: 5,061 nTPM
  • skin: 4,221 nTPM
  • pancreas: 4,056 nTPM
  • tongue: 3,876 nTPM
  • choroid plexus: 3,836 nTPM

Single-cell type

  • late spermatids: 10,329 nCPM
  • esophageal suprabasal cells: 8,780 nCPM
  • ovarian stromal cells: 7,502 nCPM
  • gastric chief cells: 7,405 nCPM
  • esophageal apical cells: 7,389 nCPM
  • suprabasal keratinocytes: 7,160 nCPM

Immune cell

  • total PBMC: 6,123 nTPM
  • memory B-cell: 4,467 nTPM
  • naive CD4 T-cell: 4,359 nTPM
  • naive B-cell: 4,278 nTPM
  • plasmacytoid DC: 4,247 nTPM
  • naive CD8 T-cell: 4,022 nTPM

Brain region

  • thalamus: 1,088 nTPM
  • white matter: 1,077 nTPM
  • spinal cord: 1,069 nTPM
  • basal ganglia: 1,001 nTPM
  • hypothalamus: 921 nTPM
  • medulla oblongata: 919 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0.01
gnomAD missense Z
0.72
DepMap mean gene effect
-2.11
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL37A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL37A as an antibody target. Whether an autoantibody or antibody against RPL37A could matter depends on whether native RPL37A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL37A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL37A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL37A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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