Seroatlas · Human Serome Atlas

IPO4

Importin-4

Also known as: FLJ23338, Imp4, IPO4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEX9
Gene: IPO4
Ensembl: ENSG00000196497
Chromosome: 14
Canonical length: 1081 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in chromatin. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1081 residues, UniProt reviewed canonical sequence.

>Q8TEX9|IPO4
     1  MESAGLEQLL RELLLPDTER IRRATEQLQI VLRAPAALPA LCDLLASAAD PQIRQFAAVL
    61  TRRRLNTRWR RLAAEQRESL KSLILTALQR ETEHCVSLSL AQLSATIFRK EGLEAWPQLL
   121  QLLQHSTHSP HSPEREMGLL LLSVVVTSRP EAFQPHHREL LRLLNETLGE VGSPGLLFYS
   181  LRTLTTMAPY LSTEDVPLAR MLVPKLIMAM QTLIPIDEAK ACEALEALDE LLESEVPVIT
   241  PYLSEVLTFC LEVARNVALG NAIRIRILCC LTFLVKVKSK ALLKNRLLPP LLHTLFPIVA
   301  AEPPPGQLDP EDQDSEEEEL EIELMGETPK HFAVQVVDML ALHLPPEKLC PQLMPMLEEA
   361  LRSESPYQRK AGLLVLAVLS DGAGDHIRQR LLPPLLQIVC KGLEDPSQVV RNAALFALGQ
   421  FSENLQPHIS SYSREVMPLL LAYLKSVPLG HTHHLAKACY ALENFVENLG PKVQPYLPEL
   481  MECMLQLLRN PSSPRAKELA VSALGAIATA AQASLLPYFP AIMEHLREFL LTGREDLQPV
   541  QIQSLETLGV LARAVGEPMR PLAEECCQLG LGLCDQVDDP DLRRCTYSLF AALSGLMGEG
   601  LAPHLEQITT LMLLSLRSTE GIVPQYDGSS SFLLFDDESD GEEEEELMDE DVEEEDDSEI
   661  SGYSVENAFF DEKEDTCAAV GEISVNTSVA FLPYMESVFE EVFKLLECPH LNVRKAAHEA
   721  LGQFCCALHK ACQSCPSEPN TAALQAALAR VVPSYMQAVN RERERQVVMA VLEALTGVLR
   781  SCGTLTLKPP GRLAELCGVL KAVLQRKTAC QDTDEEEEEE DDDQAEYDAM LLEHAGEAIP
   841  ALAAAAGGDS FAPFFAGFLP LLVCKTKQGC TVAEKSFAVG TLAETIQGLG AASAQFVSRL
   901  LPVLLSTAQE ADPEVRSNAI FGMGVLAEHG GHPAQEHFPK LLGLLFPLLA RERHDRVRDN
   961  ICGALARLLM ASPTRKPEPQ VLAALLHALP LKEDLEEWVT IGRLFSFLYQ SSPDQVIDVA
  1021  PELLRICSLI LADNKIPPDT KAALLLLLTF LAKQHTDSFQ AALGSLPVDK AQELQAVLGL
  1081  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
pancreas: 36 nTPM
skeletal muscle: 29 nTPM
kidney: 20 nTPM
liver: 20 nTPM
adrenal gland: 18 nTPM

Single-cell type

ependymal cells: 3.2 nCPM
astrocytes: 2.3 nCPM
bergmann glia: 2 nCPM
choroid plexus epithelial cells: 1.8 nCPM
oligodendrocytes: 1.8 nCPM
other brain neurons: 1.7 nCPM

Immune cell

MAIT T-cell: 3.8 nTPM
gdT-cell: 3.3 nTPM
plasmacytoid DC: 3.2 nTPM
naive CD8 T-cell: 2.9 nTPM
memory CD4 T-cell: 2.8 nTPM
memory CD8 T-cell: 2.7 nTPM

Brain region

choroid plexus: 8.3 nTPM
hypothalamus: 3 nTPM
white matter: 2.7 nTPM
pons: 2.5 nTPM
thalamus: 2.1 nTPM
amygdala: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IPO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPO4 as an antibody target. Whether an autoantibody or antibody against IPO4 could matter depends on whether native IPO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IPO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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