Seroatlas · Human Serome Atlas

NPM3

Nucleoplasmin-3

Also known as: NPM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75607
Gene: NPM3
Ensembl: ENSG00000107833
Chromosome: 10
Canonical length: 178 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>O75607|NPM3
     1  MAAGTAAALA FLSQESRTRA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF TFKVEEEDDA
    61  EHVLALTMLC LTEGAKDECN VVEVVARNHD HQEIAVPVAN LKLSCQPMLS LDDFQLQPPV
   121  TFRLKSGSGP VRITGRHQIV TMSNDVSEEE SEEEEEDSDE EEVELCPILP AKKQGGRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

pancreas: 29 nTPM
ovary: 27 nTPM
esophagus: 26 nTPM
bone marrow: 24 nTPM
tonsil: 23 nTPM
lymph node: 21 nTPM

Single-cell type

esophageal basal cells: 229 nCPM
migrating cytotrophoblasts: 124 nCPM
oocytes: 115 nCPM
cytotrophoblasts: 111 nCPM
decidual stromal cells: 111 nCPM
differentiating spermatogonia: 106 nCPM

Immune cell

naive CD8 T-cell: 9.4 nTPM
naive CD4 T-cell: 9 nTPM
plasmacytoid DC: 7.8 nTPM
NK-cell: 7.7 nTPM
memory CD8 T-cell: 6.5 nTPM
MAIT T-cell: 6.2 nTPM

Brain region

hypothalamus: 9.8 nTPM
basal ganglia: 6.7 nTPM
cerebral cortex: 6.1 nTPM
choroid plexus: 6 nTPM
hippocampal formation: 5.8 nTPM
white matter: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NPM3.

Disease | ImmuneIEDB

Conditions an epitope on NPM3 was assayed in.

systemic scleroderma B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.07
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NPM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPM3 as an antibody target. Whether an autoantibody or antibody against NPM3 could matter depends on whether native NPM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NPM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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