Seroatlas · Human Serome Atlas

RPL26L1

Ribosomal protein uL24-like

Also known as: RL26L_HUMAN, RPL26P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNX3
Gene: RPL26L1
Ensembl: ENSG00000037241
Chromosome: 5
Canonical length: 145 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q9UNX3|RPL26L1
     1  MKFNPFVTSD RSKNRKRHFN APSHVRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG
    61  HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE
   121  RKAKSRQVGK EKGKYKEELI EKMQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL26L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

testis: 87 nTPM
kidney: 46 nTPM
liver: 45 nTPM
adrenal gland: 43 nTPM
bone marrow: 37 nTPM
skeletal muscle: 36 nTPM

Single-cell type

late primary spermatocytes: 611 nCPM
early spermatids: 334 nCPM
early primary spermatocytes: 188 nCPM
oocytes: 161 nCPM
differentiating spermatogonia: 146 nCPM
esophageal basal cells: 135 nCPM

Immune cell

myeloid DC: 100 nTPM
classical monocyte: 87 nTPM
intermediate monocyte: 81 nTPM
non-classical monocyte: 73 nTPM
plasmacytoid DC: 68 nTPM
T-reg: 56 nTPM

Brain region

cerebral cortex: 26 nTPM
hippocampal formation: 26 nTPM
pons: 26 nTPM
hypothalamus: 24 nTPM
cerebellum: 24 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL26L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL26L1 as an antibody target. Whether an autoantibody or antibody against RPL26L1 could matter depends on whether native RPL26L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL26L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL26L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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