Seroatlas · Human Serome Atlas

RPL10A

Large ribosomal subunit protein uL1

Also known as: Csa-19, L10A, NEDD6, RL10A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62906
Gene
RPL10A
Ensembl
ENSG00000198755
Chromosome
6
Canonical length
217 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P62906|RPL10A
     1  MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS GTVRLKSTPR
    61  PKFSVCVLGD QQHCDEAKAV DIPHMDIEAL KKLNKNKKLV KKLAKKYDAF LASESLIKQI
   121  PRILGPGLNK AGKFPSLLTH NENMVAKVDE VKSTIKFQMK KVLCLAVAVG HVKMTDDELV
   181  YNIHLAVNFL VSLLKKNWQN VRALYIKSTM GKPQRLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
3,333 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,333 nTPM
  • skin: 2,060 nTPM
  • breast: 1,956 nTPM
  • bone marrow: 1,933 nTPM
  • pancreas: 1,804 nTPM
  • fallopian tube: 1,797 nTPM

Single-cell type

  • decidual stromal cells: 8,700 nCPM
  • esophageal suprabasal cells: 8,236 nCPM
  • esophageal basal cells: 7,877 nCPM
  • extravillous trophoblasts: 6,872 nCPM
  • migrating cytotrophoblasts: 5,465 nCPM
  • breast secretory cells: 5,157 nCPM

Immune cell

  • total PBMC: 5,504 nTPM
  • naive CD4 T-cell: 3,264 nTPM
  • memory B-cell: 3,190 nTPM
  • naive B-cell: 2,820 nTPM
  • MAIT T-cell: 2,636 nTPM
  • naive CD8 T-cell: 2,611 nTPM

Brain region

  • spinal cord: 369 nTPM
  • white matter: 339 nTPM
  • thalamus: 316 nTPM
  • hypothalamus: 306 nTPM
  • medulla oblongata: 304 nTPM
  • basal ganglia: 290 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.85
gnomAD missense Z
2.06
DepMap mean gene effect
-2.11
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL10A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL10A as an antibody target. Whether an autoantibody or antibody against RPL10A could matter depends on whether native RPL10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL10A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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