Seroatlas · Human Serome Atlas

RPS15

Small ribosomal subunit protein uS19

Also known as: MGC111130, RIG, RS15_HUMAN, S15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62841
Gene
RPS15
Ensembl
ENSG00000115268
Chromosome
19
Canonical length
145 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>P62841|RPS15
     1  MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL
    61  RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS
   121  ITYKPVKHGR PGIGATHSSR FIPLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
2,731 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,731 nTPM
  • skin: 2,652 nTPM
  • pancreas: 2,334 nTPM
  • esophagus: 1,875 nTPM
  • skeletal muscle: 1,851 nTPM
  • cervix: 1,731 nTPM

Single-cell type

  • esophageal suprabasal cells: 8,565 nCPM
  • suprabasal keratinocytes: 8,284 nCPM
  • esophageal basal cells: 7,794 nCPM
  • extravillous trophoblasts: 7,466 nCPM
  • gastric progenitor cells: 7,016 nCPM
  • decidual stromal cells: 6,985 nCPM

Immune cell

  • total PBMC: 7,263 nTPM
  • memory B-cell: 5,361 nTPM
  • naive B-cell: 4,893 nTPM
  • naive CD4 T-cell: 4,354 nTPM
  • T-reg: 3,674 nTPM
  • memory CD4 T-cell: 3,628 nTPM

Brain region

  • white matter: 698 nTPM
  • thalamus: 693 nTPM
  • spinal cord: 689 nTPM
  • basal ganglia: 660 nTPM
  • medulla oblongata: 629 nTPM
  • amygdala: 608 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.83
gnomAD missense Z
1.78
DepMap mean gene effect
-2.21
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein uS19
  • Small ribosomal subunit protein uS19, eukaryota/archaea
  • Small ribosomal subunit protein uS19, conserved site
  • Small ribosomal subunit protein uS19, superfamily
  • Ribosomal protein S19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS15 as an antibody target. Whether an autoantibody or antibody against RPS15 could matter depends on whether native RPS15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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