Seroatlas · Human Serome Atlas

RPS2

Small ribosomal subunit protein uS5

Also known as: LLREP3, RS2_HUMAN, S2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15880
Gene
RPS2
Ensembl
ENSG00000140988
Chromosome
16
Canonical length
293 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>P15880|RPS2
     1  MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW
    61  MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ
   121  RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV
   181  PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT
   241  FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
4,435 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 4,435 nTPM
  • ovary: 3,161 nTPM
  • skin: 2,672 nTPM
  • bone marrow: 2,595 nTPM
  • esophagus: 2,472 nTPM
  • skeletal muscle: 2,308 nTPM

Single-cell type

  • extravillous trophoblasts: 16,998 nCPM
  • decidual stromal cells: 15,997 nCPM
  • esophageal basal cells: 15,790 nCPM
  • esophageal suprabasal cells: 15,705 nCPM
  • migrating cytotrophoblasts: 13,210 nCPM
  • suprabasal keratinocytes: 10,680 nCPM

Immune cell

  • memory B-cell: 1,774 nTPM
  • naive B-cell: 1,535 nTPM
  • naive CD4 T-cell: 1,372 nTPM
  • memory CD4 T-cell: 1,100 nTPM
  • naive CD8 T-cell: 1,038 nTPM
  • MAIT T-cell: 935 nTPM

Brain region

  • medulla oblongata: 588 nTPM
  • spinal cord: 548 nTPM
  • white matter: 542 nTPM
  • thalamus: 541 nTPM
  • pons: 502 nTPM
  • hypothalamus: 474 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.85
gnomAD missense Z
1.85
DepMap mean gene effect
-1.65
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS2 as an antibody target. Whether an autoantibody or antibody against RPS2 could matter depends on whether native RPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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