Seroatlas · Human Serome Atlas

RPL7A

Large ribosomal subunit protein eL8

Also known as: L7A, RL7A_HUMAN, SURF3, TRUP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62424
Gene
RPL7A
Ensembl
ENSG00000148303
Chromosome
9
Canonical length
266 aa
Protein class
Disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Vesicles

OverviewNCBI Gene

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P62424|RPL7A
     1  MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY
    61  IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK
   121  KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP
   181  YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN
   241  VLGPKSVARI AKLEKAKAKE LATKLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
3,977 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 3,977 nTPM
  • ovary: 3,756 nTPM
  • skin: 2,644 nTPM
  • esophagus: 2,632 nTPM
  • cervix: 2,119 nTPM
  • adrenal gland: 2,059 nTPM

Single-cell type

  • esophageal suprabasal cells: 8,730 nCPM
  • esophageal basal cells: 7,553 nCPM
  • decidual stromal cells: 6,799 nCPM
  • fallopian secretory cells: 6,104 nCPM
  • esophageal apical cells: 5,933 nCPM
  • pancreatic acinar cells: 5,756 nCPM

Immune cell

  • total PBMC: 960 nTPM
  • memory B-cell: 627 nTPM
  • naive CD4 T-cell: 593 nTPM
  • MAIT T-cell: 584 nTPM
  • naive CD8 T-cell: 562 nTPM
  • naive B-cell: 547 nTPM

Brain region

  • spinal cord: 307 nTPM
  • white matter: 279 nTPM
  • medulla oblongata: 264 nTPM
  • thalamus: 255 nTPM
  • basal ganglia: 249 nTPM
  • hypothalamus: 247 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL7A.

Disease | ImmuneIEDB

Conditions an epitope on RPL7A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
0.99
gnomAD missense Z
0.9
DepMap mean gene effect
-2.11
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL7A as an antibody target. Whether an autoantibody or antibody against RPL7A could matter depends on whether native RPL7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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