Seroatlas · Human Serome Atlas

RPL19

Large ribosomal subunit protein eL19

Also known as: DKFZp779D216, FLJ27452, L19, MGC71997, RL19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P84098
Gene
RPL19
Ensembl
ENSG00000108298
Chromosome
17
Canonical length
196 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>P84098|RPL19
     1  MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR
    61  ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY
   121  HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK
   181  KEEIIKTLSK EEETKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
3,515 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,515 nTPM
  • bone marrow: 3,248 nTPM
  • pancreas: 2,859 nTPM
  • skin: 2,672 nTPM
  • skeletal muscle: 2,658 nTPM
  • lymph node: 2,650 nTPM

Single-cell type

  • gastric progenitor cells: 14,562 nCPM
  • esophageal suprabasal cells: 9,960 nCPM
  • esophageal basal cells: 9,461 nCPM
  • decidual stromal cells: 6,830 nCPM
  • late spermatids: 6,585 nCPM
  • extravillous trophoblasts: 6,426 nCPM

Immune cell

  • total PBMC: 9,408 nTPM
  • naive CD4 T-cell: 4,937 nTPM
  • memory B-cell: 4,717 nTPM
  • naive B-cell: 4,369 nTPM
  • naive CD8 T-cell: 4,101 nTPM
  • memory CD4 T-cell: 3,997 nTPM

Brain region

  • spinal cord: 792 nTPM
  • white matter: 755 nTPM
  • medulla oblongata: 739 nTPM
  • basal ganglia: 713 nTPM
  • thalamus: 677 nTPM
  • hypothalamus: 637 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.98
gnomAD missense Z
2.39
DepMap mean gene effect
-2.29
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein eL19 domain
  • Large ribosomal subunit protein eL19, domain 1
  • Large ribosomal subunit protein eL19, conserved site
  • Large ribosomal subunit protein eL19, eukaryotic
  • Large ribosomal subunit protein eL19 superfamily
  • Large ribosomal subunit protein eL19
  • Ribosomal protein L19e, N-terminal domain
  • Ribosomal protein L19e, C-terminal domain
  • Ribosomal protein L19e, N-terminal domain
  • Ribosomal protein L19e, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL19 as an antibody target. Whether an autoantibody or antibody against RPL19 could matter depends on whether native RPL19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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