Seroatlas · Human Serome Atlas

RPL14

Large ribosomal subunit protein eL14

Also known as: CTG-B33, hRL14, L14, RL14, RL14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50914
Gene
RPL14
Ensembl
ENSG00000188846
Chromosome
3
Canonical length
215 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>P50914|RPL14
     1  MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF
    61  ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER KAKMTDFDRF KVMKAKKMRN
   121  RIIKNEVKKL QKAALLKASP KKAPGTKGTA AAAAAAAAAK VPAKKITAAS KKAPAQKVPA
   181  QKATGQKAAP APKAQKGQKA PAQKAPAPKA SGKKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
187 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 187 nTPM
  • pancreas: 136 nTPM
  • cervix: 123 nTPM
  • urinary bladder: 114 nTPM
  • breast: 109 nTPM
  • skin: 107 nTPM

Single-cell type

  • esophageal basal cells: 5,343 nCPM
  • esophageal suprabasal cells: 5,343 nCPM
  • extravillous trophoblasts: 5,256 nCPM
  • decidual stromal cells: 4,931 nCPM
  • migrating cytotrophoblasts: 4,930 nCPM
  • breast secretory cells: 4,282 nCPM

Immune cell

  • total PBMC: 236 nTPM
  • naive CD4 T-cell: 134 nTPM
  • naive CD8 T-cell: 127 nTPM
  • MAIT T-cell: 119 nTPM
  • memory CD4 T-cell: 111 nTPM
  • memory B-cell: 99 nTPM

Brain region

  • spinal cord: 44 nTPM
  • thalamus: 44 nTPM
  • cerebral cortex: 44 nTPM
  • medulla oblongata: 43 nTPM
  • cerebellum: 43 nTPM
  • hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.9
gnomAD missense Z
0.36
DepMap mean gene effect
-1.94
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL14 as an antibody target. Whether an autoantibody or antibody against RPL14 could matter depends on whether native RPL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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