Seroatlas · Human Serome Atlas

RPL5

Large ribosomal subunit protein uL18

Also known as: L5, PPP1R135, RL5_HUMAN, uL18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46777
Gene
RPL5
Ensembl
ENSG00000122406
Chromosome
1
Canonical length
297 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Nucleoli rim,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>P46777|RPL5
     1  MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI
    61  ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE
   121  GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF
   181  PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNS VTPDMMEEMY
   241  KKAHAAIREN PVYEKKPKKE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
3,124 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,124 nTPM
  • pancreas: 2,119 nTPM
  • breast: 1,681 nTPM
  • bone marrow: 1,644 nTPM
  • cervix: 1,634 nTPM
  • fallopian tube: 1,399 nTPM

Single-cell type

  • decidual stromal cells: 5,597 nCPM
  • fallopian secretory cells: 4,890 nCPM
  • extravillous trophoblasts: 4,784 nCPM
  • ovarian stromal cells: 4,733 nCPM
  • esophageal basal cells: 4,585 nCPM
  • epididymal efferent duct absorptive cells: 4,332 nCPM

Immune cell

  • total PBMC: 2,356 nTPM
  • naive CD4 T-cell: 1,735 nTPM
  • naive CD8 T-cell: 1,576 nTPM
  • MAIT T-cell: 1,523 nTPM
  • memory CD4 T-cell: 1,389 nTPM
  • memory B-cell: 1,325 nTPM

Brain region

  • spinal cord: 309 nTPM
  • white matter: 300 nTPM
  • hypothalamus: 300 nTPM
  • medulla oblongata: 285 nTPM
  • basal ganglia: 274 nTPM
  • thalamus: 267 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL5.

Disease | AllUniProt

Conditions RPL5 is implicated in, by any mechanism.

Disease | GeneticClinVar

89 pathogenic / likely-pathogenic of 377 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
1.9
DepMap mean gene effect
-2.55
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein uL18
  • Large ribosomal subunit protein uL18, eukaryota/archaea
  • Large ribosomal subunit protein uL18, C-terminal, eukaryotes
  • Ribosomal L18 C-terminal region
  • Ribosomal large subunit proteins 60S L5, and 50S L18

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL5 as an antibody target. Whether an autoantibody or antibody against RPL5 could matter depends on whether native RPL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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