Seroatlas · Human Serome Atlas

RPL24

Large ribosomal subunit protein eL24

Also known as: L24, RL24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P83731
Gene
RPL24
Ensembl
ENSG00000114391
Chromosome
3
Canonical length
157 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>P83731|RPL24
     1  MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK
    61  KGQSEEIQKK RTRRAVKFQR AITGASLADI MAKRNQKPEV RKAQREQAIR AAKEAKKAKQ
   121  ASKKTAMAAA KAPTKAAPKQ KIVKPVKVSA PRVGGKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
3,028 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,028 nTPM
  • pancreas: 2,259 nTPM
  • breast: 1,880 nTPM
  • cervix: 1,781 nTPM
  • bone marrow: 1,692 nTPM
  • skeletal muscle: 1,681 nTPM

Single-cell type

  • esophageal apical cells: 5,244 nCPM
  • esophageal suprabasal cells: 4,525 nCPM
  • extravillous trophoblasts: 4,130 nCPM
  • decidual stromal cells: 4,091 nCPM
  • ovarian stromal cells: 3,926 nCPM
  • pancreatic acinar cells: 3,790 nCPM

Immune cell

  • total PBMC: 4,664 nTPM
  • naive CD4 T-cell: 2,864 nTPM
  • memory CD4 T-cell: 2,293 nTPM
  • T-reg: 2,251 nTPM
  • naive CD8 T-cell: 2,237 nTPM
  • memory B-cell: 2,235 nTPM

Brain region

  • spinal cord: 417 nTPM
  • white matter: 416 nTPM
  • thalamus: 392 nTPM
  • cerebellum: 387 nTPM
  • hypothalamus: 361 nTPM
  • basal ganglia: 360 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.64
gnomAD missense Z
1.63
DepMap mean gene effect
-2.01
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL24 as an antibody target. Whether an autoantibody or antibody against RPL24 could matter depends on whether native RPL24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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