Seroatlas · Human Serome Atlas

RPL15

Large ribosomal subunit protein eL15

Also known as: EC45, L15, RL15_HUMAN, RPL10, RPLY10, RPYL10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61313
Gene
RPL15
Ensembl
ENSG00000174748
Chromosome
3
Canonical length
204 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>P61313|RPL15
     1  MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR LGYKAKQGYV
    61  IYRIRVRRGG RKRPVPKGAT YGKPVHHGVN QLKFARSLQS VAEERAGRHC GALRVLNSYW
   121  VGEDSTYKFF EVILIDPFHK AIRRNPDTQW ITKPVHKHRE MRGLTSAGRK SRGLGKGHKF
   181  HHTIGGSRRA AWRRRNTLQL HRYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
3,865 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,865 nTPM
  • bone marrow: 2,989 nTPM
  • pancreas: 2,670 nTPM
  • salivary gland: 2,387 nTPM
  • skin: 2,115 nTPM
  • thymus: 1,997 nTPM

Single-cell type

  • extravillous trophoblasts: 7,079 nCPM
  • decidual stromal cells: 6,905 nCPM
  • migrating cytotrophoblasts: 6,323 nCPM
  • late spermatids: 6,168 nCPM
  • breast secretory cells: 5,721 nCPM
  • esophageal suprabasal cells: 5,604 nCPM

Immune cell

  • total PBMC: 6,613 nTPM
  • memory B-cell: 3,491 nTPM
  • naive B-cell: 3,324 nTPM
  • naive CD4 T-cell: 3,193 nTPM
  • MAIT T-cell: 2,967 nTPM
  • myeloid DC: 2,926 nTPM

Brain region

  • spinal cord: 913 nTPM
  • thalamus: 825 nTPM
  • white matter: 803 nTPM
  • medulla oblongata: 764 nTPM
  • hypothalamus: 753 nTPM
  • basal ganglia: 719 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL15.

Disease | AllUniProt

Conditions RPL15 is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 12
  • RPL15-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.97
gnomAD missense Z
1.83
DepMap mean gene effect
-0.88
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL15 as an antibody target. Whether an autoantibody or antibody against RPL15 could matter depends on whether native RPL15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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