Seroatlas · Human Serome Atlas

RPL18

Large ribosomal subunit protein eL18

Also known as: L18, RL18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q07020
Gene
RPL18
Ensembl
ENSG00000063177
Chromosome
19
Canonical length
188 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q07020|RPL18
     1  MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP
    61  LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI
   121  LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR
   181  RASRGYKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
3,613 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,613 nTPM
  • pancreas: 3,000 nTPM
  • skin: 2,566 nTPM
  • esophagus: 2,305 nTPM
  • bone marrow: 1,863 nTPM
  • cervix: 1,805 nTPM

Single-cell type

  • esophageal apical cells: 10,031 nCPM
  • esophageal suprabasal cells: 8,046 nCPM
  • esophageal basal cells: 6,988 nCPM
  • extravillous trophoblasts: 6,683 nCPM
  • decidual stromal cells: 5,820 nCPM
  • migrating cytotrophoblasts: 5,640 nCPM

Immune cell

  • total PBMC: 3,198 nTPM
  • memory B-cell: 2,395 nTPM
  • naive CD4 T-cell: 2,382 nTPM
  • naive B-cell: 2,377 nTPM
  • naive CD8 T-cell: 1,988 nTPM
  • memory CD4 T-cell: 1,927 nTPM

Brain region

  • spinal cord: 600 nTPM
  • thalamus: 591 nTPM
  • white matter: 564 nTPM
  • amygdala: 558 nTPM
  • medulla oblongata: 554 nTPM
  • basal ganglia: 540 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL18.

Disease | AllUniProt

Conditions RPL18 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 146 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 18

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
1.85
DepMap mean gene effect
-1.66
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL18 as an antibody target. Whether an autoantibody or antibody against RPL18 could matter depends on whether native RPL18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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