Seroatlas · Human Serome Atlas

LSM12

Protein LSM12

Also known as: FLJ30656, LSM12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MHD2
Gene: LSM12
Ensembl: ENSG00000161654
Chromosome: 17
Canonical length: 195 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q3MHD2|LSM12
     1  MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP NHADILLINL
    61  QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS QAYAISAGVS LEGQQLFQTI
   121  HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN CKGKEGSALS HVRKIVEKHF RDVESQKILQ
   181  RSQAQQPQKE AALSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
retina: 29 nTPM
bone marrow: 28 nTPM
liver: 27 nTPM
esophagus: 24 nTPM
epididymis: 24 nTPM

Single-cell type

tuft cells: 58 nCPM
cone photoreceptor cells: 54 nCPM
myonuclei: 44 nCPM
rod photoreceptor cells: 37 nCPM
renal collecting duct intercalated cells: 37 nCPM
early spermatids: 27 nCPM

Immune cell

intermediate monocyte: 80 nTPM
non-classical monocyte: 79 nTPM
plasmacytoid DC: 72 nTPM
myeloid DC: 71 nTPM
classical monocyte: 62 nTPM
total PBMC: 61 nTPM

Brain region

cerebral cortex: 38 nTPM
hypothalamus: 37 nTPM
midbrain: 36 nTPM
thalamus: 33 nTPM
medulla oblongata: 32 nTPM
pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.97
gnomAD missense Z: 1.89
DepMap mean gene effect: -0.49
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

AD domain
Sm domain
LSM12, anticodon-binding domain
Protein Lsm12-like
LSM12, LSM domain
Anticodon-binding domain
LSM12, LSM domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM12 as an antibody target. Whether an autoantibody or antibody against LSM12 could matter depends on whether native LSM12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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