Seroatlas · Human Serome Atlas

RPS6

Small ribosomal subunit protein eS6

Also known as: RS6_HUMAN, S6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62753
Gene
RPS6
Ensembl
ENSG00000137154
Chromosome
9
Canonical length
249 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>P62753|RPS6
     1  MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG
    61  FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD
   121  IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV
   181  TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS
   241  TSKSESSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
4,416 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,416 nTPM
  • bone marrow: 3,760 nTPM
  • pancreas: 3,621 nTPM
  • skin: 3,404 nTPM
  • breast: 2,869 nTPM
  • lymph node: 2,768 nTPM

Single-cell type

  • esophageal suprabasal cells: 15,354 nCPM
  • esophageal basal cells: 14,206 nCPM
  • decidual stromal cells: 13,221 nCPM
  • extravillous trophoblasts: 11,769 nCPM
  • breast secretory cells: 10,399 nCPM
  • gastric progenitor cells: 10,196 nCPM

Immune cell

  • total PBMC: 14,755 nTPM
  • naive CD4 T-cell: 7,540 nTPM
  • memory B-cell: 7,134 nTPM
  • naive B-cell: 6,065 nTPM
  • naive CD8 T-cell: 6,052 nTPM
  • memory CD4 T-cell: 5,711 nTPM

Brain region

  • white matter: 841 nTPM
  • spinal cord: 794 nTPM
  • medulla oblongata: 790 nTPM
  • basal ganglia: 766 nTPM
  • thalamus: 685 nTPM
  • hypothalamus: 682 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.98
gnomAD missense Z
1.33
DepMap mean gene effect
-2.1
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein eS6
  • Small ribosomal subunit protein eS6-like
  • Small ribosomal subunit protein eS6, conserved site
  • Ribosomal protein S6e

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS6 as an antibody target. Whether an autoantibody or antibody against RPS6 could matter depends on whether native RPS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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