Seroatlas · Human Serome Atlas

STAU1

Double-stranded RNA-binding protein Staufen homolog 1

Also known as: PPP1R150, STAU, STAU1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95793
Gene
STAU1
Ensembl
ENSG00000124214
Chromosome
20
Canonical length
577 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homopolymer

OverviewNCBI Gene

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>O95793|STAU1
     1  MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP IQNSALPSAS
    61  ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ STYNYNMRGG AYPPRYFYPF
   121  PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH DAAAKALRIL QNEPLPERLE VNGRESEEEN
   181  LNKSEISQVF EIALKRNLPV NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN
   241  AAIAVLEELK KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE
   301  KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE ILGFKVPQAQ
   361  PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE DEFRMPYLSH QQLPAGILPM
   421  VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKNNISSGH
   481  VPHGPLTRPS EQLDYLSRVQ GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES
   541  CHDMAALNIL KLLSELDQQS TEMPRTGNGP MSVCGRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • liver: 115 nTPM
  • kidney: 83 nTPM
  • parathyroid gland: 77 nTPM
  • pancreas: 66 nTPM
  • thyroid gland: 65 nTPM
  • fallopian tube: 62 nTPM

Single-cell type

  • neutrophils: 471 nCPM
  • syncytiotrophoblasts: 280 nCPM
  • esophageal apical cells: 267 nCPM
  • neutrophil progenitors: 249 nCPM
  • oocytes: 249 nCPM
  • fallopian tube ciliated cells: 240 nCPM

Immune cell

  • neutrophil: 38 nTPM
  • basophil: 32 nTPM
  • T-reg: 23 nTPM
  • non-classical monocyte: 20 nTPM
  • eosinophil: 20 nTPM
  • MAIT T-cell: 20 nTPM

Brain region

  • white matter: 85 nTPM
  • medulla oblongata: 85 nTPM
  • pons: 84 nTPM
  • midbrain: 83 nTPM
  • cerebral cortex: 81 nTPM
  • spinal cord: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
1.93
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAU1 as an antibody target. Whether an autoantibody or antibody against STAU1 could matter depends on whether native STAU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAU1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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