Seroatlas · Human Serome Atlas

FAM120A

Constitutive coactivator of PPAR-gamma-like protein 1

Also known as: C9orf10, F120A_HUMAN, KIAA0183, OSSA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZB2
Gene: FAM120A
Ensembl: ENSG00000048828
Chromosome: 9
Canonical length: 1118 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1118 residues, UniProt reviewed canonical sequence.

>Q9NZB2|FAM120A
     1  MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG
    61  FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ
   121  QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH
   181  GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL
   241  GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD
   301  AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV
   361  PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN
   421  IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATNHISGNKI
   481  GWEKTGSHSE PQARGDPGDQ TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH
   541  MDITTPPLPP VAPEVLRVAE HRHKKGLMYP YIFHVLTKGE IKIAVSIEDE ANKDLPPAAL
   601  LYRPVRQYVY GVLFSLAESR KKTERLAFRK NRLPPEFSPV IIKEWAAYKG KSPQTPELVE
   661  ALAFREWTCP NLKRLWLGKA VEDKNRRMRA FLACMRSDTP AMLNPANVPT HLMVLCCVLR
   721  YMVQWPGARI LRRQELDAFL AQALSPKLYE PDQLQELKIE NLDPRGIQLS ALFMSGVDMA
   781  LFANDACGQP IPWEHCCPWM YFDGKLFQSK LLKASREKTP LIDLCDGQAD QAAKVEKMRQ
   841  SVLEGLSFSR QSHTLPFPPP PALPFYPASA YPRHFGPVPP SQGRGRGFAG VCGFGGPYGE
   901  TVATGPYRAF RVAAASGHCG AFSGSDSSRT SKSQGGVQPI PSQGGKLEIA GTVVGHWAGS
   961  RRGRGGRGPF PLQVVSVGGP ARGRPRGVIS TPVIRTFGRG GRYYGRGYKN QAAIQGRPPY
  1021  AASAEEVAKE LKSKSGESKS SAMSSDGSLA ENGVMAEEKP APQMNGSTGD ARAPSHSESA
  1081  LNNDSKTCNT NPHLNALSTD SACRREAALE AAVLNKEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM120A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 84 nTPM
skeletal muscle: 77 nTPM
colon: 71 nTPM
tongue: 67 nTPM
rectum: 67 nTPM
stomach: 67 nTPM

Single-cell type

neutrophils: 324 nCPM
monocyte progenitors: 259 nCPM
foveolar cells: 246 nCPM
neutrophil progenitors: 231 nCPM
monocytes: 223 nCPM
colonocytes: 221 nCPM

Immune cell

neutrophil: 13 nTPM
non-classical monocyte: 9.3 nTPM
T-reg: 8.3 nTPM
intermediate monocyte: 7.5 nTPM
classical monocyte: 6.5 nTPM
myeloid DC: 6.1 nTPM

Brain region

choroid plexus: 145 nTPM
medulla oblongata: 99 nTPM
thalamus: 93 nTPM
midbrain: 93 nTPM
basal ganglia: 93 nTPM
pons: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 3.35
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM120A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM120A as an antibody target. Whether an autoantibody or antibody against FAM120A could matter depends on whether native FAM120A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM120A is annotated at the cell surface, where native FAM120A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM120A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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