Seroatlas · Human Serome Atlas

RPL22L1

Ribosomal protein eL22-like

Also known as: RL22L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P5R6
Gene: RPL22L1
Ensembl: ENSG00000163584
Chromosome: 3
Canonical length: 122 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q6P5R6|RPL22L1
     1  MAPQKDRKPK RSTWRFNLDL THPVEDGIFD SGNFEQFLRE KVKVNGKTGN LGNVVHIERF
    61  KNKITVVSEK QFSKRYLKYL TKKYLKKNNL RDWLRVVASD KETYELRYFQ ISQDEDESES
   121  ED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL22L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 88 nTPM
esophagus: 73 nTPM
lymph node: 70 nTPM
spleen: 66 nTPM
appendix: 61 nTPM
tonsil: 59 nTPM

Single-cell type

esophageal basal cells: 807 nCPM
esophageal suprabasal cells: 694 nCPM
gastric progenitor cells: 542 nCPM
erythrocyte progenitors: 479 nCPM
decidual stromal cells: 458 nCPM
plasma cells: 453 nCPM

Immune cell

plasmacytoid DC: 51 nTPM
memory B-cell: 47 nTPM
naive B-cell: 35 nTPM
NK-cell: 29 nTPM
MAIT T-cell: 27 nTPM
memory CD4 T-cell: 20 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 7.7 nTPM
basal ganglia: 7.5 nTPM
pons: 7.5 nTPM
cerebral cortex: 7.2 nTPM
thalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cytoplasmic translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL22L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

G3BP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL22L1 as an antibody target. Whether an autoantibody or antibody against RPL22L1 could matter depends on whether native RPL22L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL22L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL22L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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