Seroatlas · Human Serome Atlas

PSMD14

26S proteasome non-ATPase regulatory subunit 14

Also known as: pad1, POH1, PSDE_HUMAN, Rpn11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00487
Gene
PSMD14
Ensembl
ENSG00000115233
Chromosome
2
Canonical length
310 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>O00487|PSMD14
     1  MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE
    61  FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC
   121  WLSGVDINTQ QSFEALSERA VAVVVDPIQS VKGKVVIDAF RLINANMMVL GHEPRQTTSN
   181  LGHLNKPSIQ ALIHGLNRHY YSITINYRKN ELEQKMLLNL HKKSWMEGLT LQDYSEHCKH
   241  NESVVKEMLE LAKNYNKAVE EEDKMTPEQL AIKNVGKQDP KRHLEEHVDV LMTSNIVQCL
   301  AAMLDTVVFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 119 nTPM
  • tongue: 71 nTPM
  • tonsil: 49 nTPM
  • spinal cord: 48 nTPM
  • parathyroid gland: 48 nTPM
  • cerebral cortex: 47 nTPM

Single-cell type

  • syncytiotrophoblasts: 286 nCPM
  • esophageal apical cells: 207 nCPM
  • cytotrophoblasts: 205 nCPM
  • late primary spermatocytes: 200 nCPM
  • extravillous trophoblasts: 196 nCPM
  • endometrial glandular cells: 179 nCPM

Immune cell

  • T-reg: 84 nTPM
  • myeloid DC: 75 nTPM
  • plasmacytoid DC: 75 nTPM
  • total PBMC: 73 nTPM
  • memory CD8 T-cell: 71 nTPM
  • NK-cell: 70 nTPM

Brain region

  • white matter: 45 nTPM
  • spinal cord: 40 nTPM
  • pons: 40 nTPM
  • hypothalamus: 38 nTPM
  • cerebral cortex: 37 nTPM
  • medulla oblongata: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
3.57
DepMap mean gene effect
-1.64
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD14 as an antibody target. Whether an autoantibody or antibody against PSMD14 could matter depends on whether native PSMD14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD14 is annotated as secreted, so native PSMD14 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSMD14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMD14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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