Seroatlas · Human Serome Atlas

PSMD11

26S proteasome non-ATPase regulatory subunit 11

Also known as: MGC3844, p44.5, PSD11_HUMAN, Rpn6, S9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00231
Gene: PSMD11
Ensembl: ENSG00000108671
Chromosome: 17
Canonical length: 422 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Perinuclear theca,Principal piece

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>O00231|PSMD11
     1  MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT
    61  GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME AATGQEVELC LECIEWAKSE
   121  KRTFLRQALE ARLVSLYFDT KRYQEALHLG SQLLRELKKM DDKALLVEVQ LLESKTYHAL
   181  SNLPKARAAL TSARTTANAI YCPPKLQATL DMQSGIIHAA EEKDWKTAYS YFYEAFEGYD
   241  SIDSPKAITS LKYMLLCKIM LNTPEDVQAL VSGKLALRYA GRQTEALKCV AQASKNRSLA
   301  DFEKALTDYR AELRDDPIIS THLAKLYDNL LEQNLIRVIE PFSRVQIEHI SSLIKLSKAD
   361  VERKLSQMIL DKKFHGILDQ GEGVLIIFDE PPVDKTYEAA LETIQNMSKV VDSLYNKAKK
   421  LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 97 nTPM
tongue: 55 nTPM
esophagus: 37 nTPM
tonsil: 37 nTPM
heart muscle: 36 nTPM
thymus: 36 nTPM

Single-cell type

syncytiotrophoblasts: 411 nCPM
esophageal apical cells: 235 nCPM
early spermatids: 228 nCPM
cytotrophoblasts: 221 nCPM
late primary spermatocytes: 221 nCPM
migrating cytotrophoblasts: 197 nCPM

Immune cell

T-reg: 52 nTPM
basophil: 48 nTPM
NK-cell: 48 nTPM
myeloid DC: 47 nTPM
non-classical monocyte: 46 nTPM
total PBMC: 46 nTPM

Brain region

white matter: 57 nTPM
cerebral cortex: 55 nTPM
pons: 53 nTPM
medulla oblongata: 49 nTPM
hippocampal formation: 48 nTPM
thalamus: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMD11.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature
PSMD11-associated obesity and neurodevelopmental disorder
PSMD11-Related Disorders

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.61
DepMap mean gene effect: -1.91
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural molecule activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proteasome component (PCI) domain
Tetratricopeptide-like helical domain superfamily
Winged helix DNA-binding domain superfamily
26S Proteasome and COP9 Signalosome Components
PCI domain
26S proteasome regulatory subunit Rpn6, N-terminal
6S proteasome subunit Rpn6, C-terminal helix domain
26S proteasome regulatory subunit RPN6 N-terminal domain
26S proteasome subunit RPN6 C-terminal helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD11 as an antibody target. Whether an autoantibody or antibody against PSMD11 could matter depends on whether native PSMD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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