Seroatlas · Human Serome Atlas

PSMD6

26S proteasome non-ATPase regulatory subunit 6

Also known as: KIAA0107, p44S10, PSMD6_HUMAN, Rpn7, S10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15008
Gene: PSMD6
Ensembl: ENSG00000163636
Chromosome: 3
Canonical length: 389 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q15008|PSMD6
     1  MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
    61  LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
   121  LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
   181  KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
   241  IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
   301  IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD
   361  SKNWQYQETI KKGDLLLNRV QKLSRVINM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 269 nTPM

Expression across tissuesHPA

Tissue

pancreas: 269 nTPM
skeletal muscle: 161 nTPM
testis: 113 nTPM
bone marrow: 109 nTPM
tongue: 85 nTPM
heart muscle: 74 nTPM

Single-cell type

late spermatids: 1,260 nCPM
late primary spermatocytes: 636 nCPM
early spermatids: 502 nCPM
epicardial cells: 466 nCPM
syncytiotrophoblasts: 363 nCPM
oocytes: 345 nCPM

Immune cell

total PBMC: 167 nTPM
eosinophil: 141 nTPM
non-classical monocyte: 141 nTPM
neutrophil: 140 nTPM
T-reg: 138 nTPM
intermediate monocyte: 133 nTPM

Brain region

pons: 41 nTPM
spinal cord: 40 nTPM
white matter: 40 nTPM
cerebral cortex: 38 nTPM
midbrain: 37 nTPM
medulla oblongata: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.26
DepMap mean gene effect: -2.01
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proteasome component (PCI) domain
Tetratricopeptide-like helical domain superfamily
26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
Winged helix DNA-binding domain superfamily
26S proteasome regulatory subunit Rpn7, N-terminal
PCI domain
26S proteasome subunit RPN7
26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix
26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix

KeywordsUniProt

Proteasome

InteractionsUniProt · HPA

Protein binding partners of PSMD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD6 as an antibody target. Whether an autoantibody or antibody against PSMD6 could matter depends on whether native PSMD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD6 is annotated as secreted, so native PSMD6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSMD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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