Seroatlas · Human Serome Atlas

PSMA3

Proteasome subunit alpha type-3

Also known as: HC8, PSA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25788
Gene: PSMA3
Ensembl: ENSG00000100567
Chromosome: 14
Canonical length: 255 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P25788|PSMA3
     1  MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE
    61  EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV
   121  HAYTLYSAVR PFGCSFMLGS YSVNDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL
   181  QMKEMTCRDI VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TNGRHEIVPK DIREEAEKYA
   241  KESLKEEDES DDDNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 168 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 168 nTPM
liver: 152 nTPM
tongue: 122 nTPM
epididymis: 121 nTPM
thymus: 101 nTPM
lymph node: 97 nTPM

Single-cell type

syncytiotrophoblasts: 494 nCPM
cytotrophoblasts: 470 nCPM
oocytes: 442 nCPM
migrating cytotrophoblasts: 427 nCPM
extravillous trophoblasts: 315 nCPM
esophageal basal cells: 302 nCPM

Immune cell

plasmacytoid DC: 123 nTPM
T-reg: 113 nTPM
intermediate monocyte: 99 nTPM
basophil: 95 nTPM
total PBMC: 95 nTPM
NK-cell: 94 nTPM

Brain region

white matter: 39 nTPM
spinal cord: 37 nTPM
hypothalamus: 36 nTPM
cerebellum: 35 nTPM
choroid plexus: 34 nTPM
pons: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMA3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 255 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 1, DIGENIC

Disease | ImmuneIEDB

Conditions an epitope on PSMA3 was assayed in.

carbamazepine allergy T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.98
gnomAD missense Z: 1.76
DepMap mean gene effect: -2.6
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular functions

ubiquitin protein ligase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA3 as an antibody target. Whether an autoantibody or antibody against PSMA3 could matter depends on whether native PSMA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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