PSMD10
26S proteasome non-ATPase regulatory subunit 10
Also known as: p28, PSD10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75832
- Gene
- PSMD10
- Ensembl
- ENSG00000101843
- Chromosome
- X
- Canonical length
- 226 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Microtubules,Primary cilium,Primary cilium tip,Cytosol,Perinuclear theca,Calyx,Mid piece,Principal piece
OverviewNCBI Gene
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
Canonical amino-acid sequenceUniProt
226 residues, UniProt reviewed canonical sequence.
>O75832|PSMD10
1 MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL
61 QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE
121 IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC
181 DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PSMD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 80 nTPM
Expression across tissuesHPA
Tissue
- hypothalamus: 80 nTPM
- spinal cord: 67 nTPM
- midbrain: 62 nTPM
- amygdala: 55 nTPM
- cerebral cortex: 54 nTPM
- basal ganglia: 50 nTPM
Single-cell type
- oocytes: 157 nCPM
- esophageal apical cells: 64 nCPM
- fallopian tube ciliated cells: 56 nCPM
- megakaryocytes: 56 nCPM
- early primary spermatocytes: 53 nCPM
- parietal cells: 51 nCPM
Immune cell
- basophil: 84 nTPM
- eosinophil: 73 nTPM
- non-classical monocyte: 72 nTPM
- total PBMC: 70 nTPM
- NK-cell: 59 nTPM
- intermediate monocyte: 58 nTPM
Brain region
- pons: 62 nTPM
- hypothalamus: 57 nTPM
- midbrain: 56 nTPM
- white matter: 56 nTPM
- medulla oblongata: 52 nTPM
- spinal cord: 51 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.78
- gnomAD pLI
- 0.5
- gnomAD missense Z
- 0.88
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- negative regulation of apoptotic process
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of MAPK cascade
- negative regulation of release of cytochrome c from mitochondria
- negative regulation of transcription by RNA polymerase II
- positive regulation of cell growth
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein ubiquitination
- proteasome regulatory particle assembly
- regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Ankyrin repeat
- Ankyrin repeat-containing domain superfamily
- Ankyrin repeat
- Ankyrin repeats (3 copies)
- Ankyrin repeat domain-containing protein 49
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PSMD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PSMD10 as an antibody target. Whether an autoantibody or antibody against PSMD10 could matter depends on whether native PSMD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PSMD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PSMD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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