Seroatlas · Human Serome Atlas

PSMD13

26S proteasome non-ATPase regulatory subunit 13

Also known as: p40.5, PSD13_HUMAN, Rpn9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNM6
Gene
PSMD13
Ensembl
ENSG00000185627
Chromosome
11
Canonical length
376 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q9UNM6|PSMD13
     1  MKDVPGFLQQ SQNSGPGQPA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY
    61  ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT REKVKSSDEA VILCKTAIGA
   121  LKLNIGDLQV TKETIEDVEE MLNNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL
   181  GCVDIKDLPV SEQQERAFTL GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF
   241  NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
   301  KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV
   361  KSMEMLVEHQ AHDILT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
163 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 163 nTPM
  • tongue: 116 nTPM
  • thymus: 85 nTPM
  • tonsil: 81 nTPM
  • heart muscle: 77 nTPM
  • spleen: 75 nTPM

Single-cell type

  • syncytiotrophoblasts: 250 nCPM
  • cytotrophoblasts: 193 nCPM
  • extravillous trophoblasts: 168 nCPM
  • migrating cytotrophoblasts: 163 nCPM
  • megakaryocytes: 161 nCPM
  • esophageal apical cells: 132 nCPM

Immune cell

  • total PBMC: 286 nTPM
  • basophil: 199 nTPM
  • non-classical monocyte: 196 nTPM
  • myeloid DC: 176 nTPM
  • intermediate monocyte: 173 nTPM
  • classical monocyte: 172 nTPM

Brain region

  • pons: 36 nTPM
  • hypothalamus: 32 nTPM
  • white matter: 32 nTPM
  • spinal cord: 29 nTPM
  • medulla oblongata: 27 nTPM
  • midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
0.63
DepMap mean gene effect
-1.01
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD13 as an antibody target. Whether an autoantibody or antibody against PSMD13 could matter depends on whether native PSMD13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD13 is annotated as secreted, so native PSMD13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSMD13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMD13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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