Seroatlas · Human Serome Atlas

ZFAND1

AN1-type zinc finger protein 1

Also known as: FLJ14007, ZFAN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCF1
Gene: ZFAND1
Ensembl: ENSG00000104231
Chromosome: 8
Canonical length: 268 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Enables proteasome binding activity. Involved in cellular response to arsenite ion; positive regulation of intracellular protein transport; and stress granule disassembly. Located in cytoplasmic stress granule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>Q8TCF1|ZFAND1
     1  MAELDIGQHC QVEHCRQRDF LPFVCDDCSG IFCLEHRSRE SHGCPEVTVI NERLKTDQHT
    61  SYPCSFKDCA ERELVAVICP YCEKNFCLRH RHQSDHECEK LEIPKPRMAA TQKLVKDIID
   121  SKTGETASKR WKGAKNSETA AKVALMKLKM HADGDKSLPQ TERIYFQVFL PKGSKEKSKP
   181  MFFCHRWSIG KAIDFAASLA RLKNDNNKFT AKKLRLCHIT SGEALPLDHT LETWIAKEDC
   241  PLYNGGNIIL EYLNDEEQFC KNVESYLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 54 nTPM
pancreas: 51 nTPM
ovary: 50 nTPM
blood vessel: 43 nTPM
breast: 39 nTPM
salivary gland: 38 nTPM

Single-cell type

gastric chief cells: 133 nCPM
gastric progenitor cells: 118 nCPM
decidual stromal cells: 87 nCPM
pancreatic acinar cells: 86 nCPM
parietal cells: 81 nCPM
esophageal basal cells: 75 nCPM

Immune cell

naive CD4 T-cell: 47 nTPM
T-reg: 44 nTPM
myeloid DC: 41 nTPM
NK-cell: 37 nTPM
MAIT T-cell: 37 nTPM
memory B-cell: 37 nTPM

Brain region

cerebellum: 33 nTPM
hypothalamus: 30 nTPM
pons: 29 nTPM
white matter: 27 nTPM
cerebral cortex: 27 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, AN1-type
AN1-like Zinc finger
AN1-like Zinc finger
ZFAND1-like, ubiquitin-like domain
ZFAND1-like ubiquitin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFAND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND1 as an antibody target. Whether an autoantibody or antibody against ZFAND1 could matter depends on whether native ZFAND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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