Seroatlas · Human Serome Atlas

PSMB6

Proteasome subunit beta type-6

Also known as: DELTA, PSB6_HUMAN, Y

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28072
Gene
PSMB6
Ensembl
ENSG00000142507
Chromosome
17
Canonical length
239 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>P28072|PSMB6
     1  MAATLLAARG AGPAPAWGPE AFTPDWESRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI
    61  ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM
   121  CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQSFA IGGSGSSYIY GYVDATYREG
   181  MTKEECLQFT ANALALAMER DGSSGGVIRL AAIAESGVER QVLLGDQIPK FAVATLPPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
362 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 362 nTPM
  • tongue: 317 nTPM
  • heart muscle: 200 nTPM
  • choroid plexus: 196 nTPM
  • liver: 172 nTPM
  • parathyroid gland: 163 nTPM

Single-cell type

  • esophageal suprabasal cells: 751 nCPM
  • syncytiotrophoblasts: 740 nCPM
  • esophageal apical cells: 729 nCPM
  • cytotrophoblasts: 694 nCPM
  • esophageal basal cells: 582 nCPM
  • migrating cytotrophoblasts: 568 nCPM

Immune cell

  • total PBMC: 818 nTPM
  • memory B-cell: 672 nTPM
  • naive B-cell: 645 nTPM
  • myeloid DC: 626 nTPM
  • classical monocyte: 605 nTPM
  • intermediate monocyte: 591 nTPM

Brain region

  • white matter: 75 nTPM
  • pons: 72 nTPM
  • hypothalamus: 70 nTPM
  • cerebellum: 70 nTPM
  • choroid plexus: 69 nTPM
  • medulla oblongata: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.02
gnomAD missense Z
1.46
DepMap mean gene effect
-1.72
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB6 as an antibody target. Whether an autoantibody or antibody against PSMB6 could matter depends on whether native PSMB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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