Seroatlas · Human Serome Atlas

PSMA5

Proteasome subunit alpha type-5

Also known as: PSA5_HUMAN, ZETA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28066
Gene
PSMA5
Ensembl
ENSG00000143106
Chromosome
1
Canonical length
241 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>P28066|PSMA5
     1  MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVCLAV EKRITSPLME
    61  PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW FTYNETMTVE SVTQAVSNLA
   121  LQFGEEDADP GAMSRPFGVA LLFGGVDEKG PQLFHMDPSG TFVQCDARAI GSASEGAQSS
   181  LQEVYHKSMT LKEAIKSSLI ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD
   241  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • liver: 19 nTPM
  • lymph node: 12 nTPM
  • cerebral cortex: 11 nTPM
  • kidney: 10 nTPM
  • thyroid gland: 9.5 nTPM
  • tonsil: 8.7 nTPM

Single-cell type

  • megakaryocytes: 291 nCPM
  • syncytiotrophoblasts: 288 nCPM
  • cytotrophoblasts: 284 nCPM
  • migrating cytotrophoblasts: 269 nCPM
  • esophageal suprabasal cells: 251 nCPM
  • esophageal basal cells: 237 nCPM

Immune cell

  • T-reg: 11 nTPM
  • basophil: 11 nTPM
  • naive CD8 T-cell: 9.8 nTPM
  • naive CD4 T-cell: 9.7 nTPM
  • memory CD4 T-cell: 9 nTPM
  • MAIT T-cell: 8.4 nTPM

Brain region

  • cerebral cortex: 18 nTPM
  • hippocampal formation: 15 nTPM
  • white matter: 15 nTPM
  • hypothalamus: 14 nTPM
  • basal ganglia: 12 nTPM
  • medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
0.99
gnomAD missense Z
2.81
DepMap mean gene effect
-1.94
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA5 as an antibody target. Whether an autoantibody or antibody against PSMA5 could matter depends on whether native PSMA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...