Seroatlas · Human Serome Atlas

PSMB3

Proteasome subunit beta type-3

Also known as: HC10-II, MGC4147, PSB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49720
Gene
PSMB3
Ensembl
ENSG00000277791
Chromosome
17
Canonical length
205 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P49720|PSMB3
     1  MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV
    61  QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF
   121  ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV
   181  SGMGVIVHII EKDKITTRTL KARMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
197 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 197 nTPM
  • liver: 178 nTPM
  • heart muscle: 149 nTPM
  • adrenal gland: 135 nTPM
  • bone marrow: 131 nTPM
  • lymph node: 128 nTPM

Single-cell type

  • gastric progenitor cells: 778 nCPM
  • syncytiotrophoblasts: 532 nCPM
  • extravillous trophoblasts: 487 nCPM
  • cytotrophoblasts: 483 nCPM
  • hofbauer cells: 452 nCPM
  • esophageal suprabasal cells: 434 nCPM

Immune cell

  • neutrophil: 574 nTPM
  • total PBMC: 374 nTPM
  • plasmacytoid DC: 354 nTPM
  • classical monocyte: 325 nTPM
  • myeloid DC: 275 nTPM
  • intermediate monocyte: 273 nTPM

Brain region

  • thalamus: 61 nTPM
  • hypothalamus: 58 nTPM
  • white matter: 56 nTPM
  • hippocampal formation: 50 nTPM
  • cerebral cortex: 48 nTPM
  • midbrain: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
1.51
DepMap mean gene effect
-2.68
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB3 as an antibody target. Whether an autoantibody or antibody against PSMB3 could matter depends on whether native PSMB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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