Seroatlas · Human Serome Atlas

PSMA7

Proteasome subunit alpha type-7

Also known as: C6, HSPC, PSA7_HUMAN, RC6-1, XAPC7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14818
Gene
PSMA7
Ensembl
ENSG00000101182
Chromosome
20
Canonical length
248 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Principal piece

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>O14818|PSMA7
     1  MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR
    61  KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ
   121  SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA
   181  IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE
   241  KKKQKKAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
740 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 740 nTPM
  • tongue: 350 nTPM
  • heart muscle: 258 nTPM
  • bone marrow: 246 nTPM
  • adipose tissue: 220 nTPM
  • blood vessel: 211 nTPM

Single-cell type

  • gastric progenitor cells: 1,353 nCPM
  • esophageal suprabasal cells: 1,124 nCPM
  • esophageal basal cells: 1,107 nCPM
  • syncytiotrophoblasts: 1,048 nCPM
  • extravillous trophoblasts: 968 nCPM
  • hofbauer cells: 946 nCPM

Immune cell

  • total PBMC: 1,131 nTPM
  • eosinophil: 804 nTPM
  • basophil: 757 nTPM
  • T-reg: 726 nTPM
  • non-classical monocyte: 724 nTPM
  • intermediate monocyte: 693 nTPM

Brain region

  • white matter: 128 nTPM
  • thalamus: 116 nTPM
  • hypothalamus: 114 nTPM
  • cerebellum: 113 nTPM
  • pons: 112 nTPM
  • spinal cord: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
2.34
DepMap mean gene effect
-2.36
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA7 as an antibody target. Whether an autoantibody or antibody against PSMA7 could matter depends on whether native PSMA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMA7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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