Seroatlas · Human Serome Atlas

PSMA2

Proteasome subunit alpha type-2

Also known as: HC3, MU, PMSA2, PSA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25787
Gene
PSMA2
Ensembl
ENSG00000106588
Chromosome
7
Canonical length
234 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>P25787|PSMA2
     1  MAERGYSFSL TTFSPSGKLV QIEYALAAVA GGAPSVGIKA ANGVVLATEK KQKSILYDER
    61  SVHKVEPITK HIGLVYSGMG PDYRVLVHRA RKLAQQYYLV YQEPIPTAQL VQRVASVMQE
   121  YTQSGGVRPF GVSLLICGWN EGRPYLFQSD PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE
   181  DLELEDAIHT AILTLKESFE GQMTEDNIEV GICNEAGFRR LTPTEVKDYL AAIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
298 nTPM

Expression across tissuesHPA

Tissue

  • liver: 298 nTPM
  • skeletal muscle: 218 nTPM
  • thymus: 128 nTPM
  • bone marrow: 113 nTPM
  • heart muscle: 113 nTPM
  • tongue: 112 nTPM

Single-cell type

  • oligodendrocytes: 11 nCPM
  • other brain neurons: 9.5 nCPM
  • bergmann glia: 7.4 nCPM
  • oligodendrocyte progenitor cells: 7.4 nCPM
  • brain excitatory neurons: 7.1 nCPM
  • ependymal cells: 5.5 nCPM

Immune cell

  • total PBMC: 364 nTPM
  • eosinophil: 354 nTPM
  • basophil: 282 nTPM
  • T-reg: 242 nTPM
  • plasmacytoid DC: 225 nTPM
  • non-classical monocyte: 211 nTPM

Brain region

  • white matter: 33 nTPM
  • spinal cord: 24 nTPM
  • hypothalamus: 20 nTPM
  • choroid plexus: 19 nTPM
  • medulla oblongata: 18 nTPM
  • cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
2.26
DepMap mean gene effect
-2.42
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA2 as an antibody target. Whether an autoantibody or antibody against PSMA2 could matter depends on whether native PSMA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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