Seroatlas · Human Serome Atlas

PSMA1

Proteasome subunit alpha type-1

Also known as: HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30, PSA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25786
Gene: PSMA1
Ensembl: ENSG00000129084
Chromosome: 11
Canonical length: 263 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Centrosome

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>P25786|PSMA1
     1  MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ
    61  KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT
   121  QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM
   181  ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP
   241  QRKAQPAQPA DEPAEKADEP MEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 219 nTPM
tongue: 143 nTPM
heart muscle: 132 nTPM
liver: 130 nTPM
bone marrow: 128 nTPM
thymus: 114 nTPM

Single-cell type

microglia: 376 nCPM
adipocytes: 257 nCPM
neutrophils: 181 nCPM
pancreatic islet cells: 136 nCPM
thyrotrophs: 131 nCPM
salivary acinar cells: 123 nCPM

Immune cell

myeloid DC: 244 nTPM
total PBMC: 236 nTPM
classical monocyte: 192 nTPM
T-reg: 155 nTPM
NK-cell: 145 nTPM
intermediate monocyte: 140 nTPM

Brain region

hypothalamus: 68 nTPM
pons: 57 nTPM
choroid plexus: 56 nTPM
cerebral cortex: 56 nTPM
white matter: 56 nTPM
basal ganglia: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.98
gnomAD missense Z: 1.89
DepMap mean gene effect: -2.25
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipopolysaccharide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA1 as an antibody target. Whether an autoantibody or antibody against PSMA1 could matter depends on whether native PSMA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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