Seroatlas · Human Serome Atlas

PSMB5

Proteasome subunit beta type-5

Also known as: MB1, PSB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28074
Gene
PSMB5
Ensembl
ENSG00000100804
Chromosome
14
Canonical length
263 aa
Protein class
Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Mid piece,Principal piece

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>P28074|PSMB5
     1  MALASVLERP LPVNQRGFFG LGGRADLLDL GPGSLSDGLS LAAPGWGVPE EPGIEMLHGT
    61  TTLAFKFRHG VIVAADSRAT AGAYIASQTV KKVIEINPYL LGTMAGGAAD CSFWERLLAR
   121  QCRIYELRNK ERISVAAASK LLANMVYQYK GMGLSMGTMI CGWDKRGPGL YYVDSEGNRI
   181  SGATFSVGSG SVYAYGVMDR GYSYDLEVEQ AYDLARRAIY QATYRDAYSG GAVNLYHVRE
   241  DGWIRVSSDN VADLHEKYSG STP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
383 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 383 nTPM
  • tongue: 256 nTPM
  • choroid plexus: 212 nTPM
  • heart muscle: 151 nTPM
  • parathyroid gland: 135 nTPM
  • adrenal gland: 130 nTPM

Single-cell type

  • esophageal suprabasal cells: 539 nCPM
  • extravillous trophoblasts: 521 nCPM
  • esophageal basal cells: 490 nCPM
  • syncytiotrophoblasts: 484 nCPM
  • cytotrophoblasts: 477 nCPM
  • migrating cytotrophoblasts: 471 nCPM

Immune cell

  • plasmacytoid DC: 173 nTPM
  • total PBMC: 148 nTPM
  • myeloid DC: 138 nTPM
  • naive CD4 T-cell: 135 nTPM
  • classical monocyte: 128 nTPM
  • intermediate monocyte: 126 nTPM

Brain region

  • pons: 112 nTPM
  • white matter: 111 nTPM
  • spinal cord: 104 nTPM
  • cerebellum: 102 nTPM
  • choroid plexus: 102 nTPM
  • hypothalamus: 102 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMB5.

Disease | ImmuneIEDB

Conditions an epitope on PSMB5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
1.04
DepMap mean gene effect
-1.7
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB5 as an antibody target. Whether an autoantibody or antibody against PSMB5 could matter depends on whether native PSMB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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