Seroatlas · Human Serome Atlas

PSMB2

Proteasome subunit beta type-2

Also known as: HC7-I, PSB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49721
Gene
PSMB2
Ensembl
ENSG00000126067
Chromosome
1
Canonical length
201 aa
Protein class
Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P49721|PSMB2
     1  MEYLIGIQGP DYVLVASDRV AASNIVQMKD DHDKMFKMSE KILLLCVGEA GDTVQFAEYI
    61  QKNVQLYKMR NGYELSPTAA ANFTRRNLAD CLRSRTPYHV NLLLAGYDEH EGPALYYMDY
   121  LAALAKAPFA AHGYGAFLTL SILDRYYTPT ISRERAVELL RKCLEELQKR FILNLPTFSV
   181  RIIDKNGIHD LDNISFPKQG S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 28 nTPM
  • liver: 23 nTPM
  • bone marrow: 20 nTPM
  • thymus: 19 nTPM
  • tonsil: 16 nTPM
  • spinal cord: 15 nTPM

Single-cell type

  • syncytiotrophoblasts: 530 nCPM
  • cytotrophoblasts: 484 nCPM
  • migrating cytotrophoblasts: 450 nCPM
  • extravillous trophoblasts: 397 nCPM
  • gastric progenitor cells: 301 nCPM
  • esophageal basal cells: 300 nCPM

Immune cell

  • non-classical monocyte: 36 nTPM
  • intermediate monocyte: 30 nTPM
  • plasmacytoid DC: 27 nTPM
  • myeloid DC: 26 nTPM
  • T-reg: 26 nTPM
  • total PBMC: 26 nTPM

Brain region

  • pons: 19 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 18 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 17 nTPM
  • medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
1.26
DepMap mean gene effect
-1.97
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB2 as an antibody target. Whether an autoantibody or antibody against PSMB2 could matter depends on whether native PSMB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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