26S Proteasome Regulatory ATPase

Definition

This family of proteins is involved in the ATP-dependent degradation of ubiquitinated proteins. Members function as regulatory subunits within the 26S proteasome complex, which plays a crucial role in maintaining cellular protein homeostasis. They participate in unfolding ubiquitinated target proteins that are then translocated into a proteolytic chamber for degradation into peptides. This process is essential for the removal of misfolded or damaged proteins and for regulating the levels of proteins involved in various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. Some family members are also implicated in the recognition, binding, and translocation of substrate proteins into the archaeal 20S proteasome core particle, essential for proteolytic gate opening.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• PSMC1
• PSMC2
• PSMC3
• PSMC4
• PSMC5
• PSMC6