Seroatlas · Human Serome Atlas

AKIRIN2

Akirin-2

Also known as: AKIR2_HUMAN, C6orf166, dJ486L4.2, FLJ10342

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53H80
Gene: AKIRIN2
Ensembl: ENSG00000135334
Chromosome: 6
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables enzyme binding activity; identical protein binding activity; and protein-macromolecule adaptor activity. Involved in proteasome localization and protein import into nucleus. Acts upstream of with a positive effect on nuclear protein quality control by the ubiquitin-proteasome system. Located in nucleoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q53H80|AKIRIN2
     1  MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPTSAAASP LSAAAATAAS FSAAAASPQK
    61  YLRMEPSPFG DVSSRLTTEQ ILYNIKQEYK RMQKRRHLET SFQQTDPCCT SDAQPHAFLL
   121  SGPASPGTSS AASSPLKKEQ PLFTLRQVGM ICERLLKERE EKVREEYEEI LNTKLAEQYD
   181  AFVKFTHDQI MRRYGEQPAS YVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKIRIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 86 nTPM
bone marrow: 67 nTPM
spleen: 44 nTPM
tongue: 40 nTPM
cerebral cortex: 33 nTPM
adrenal gland: 33 nTPM

Single-cell type

platelets: 701 nCPM
esophageal apical cells: 531 nCPM
neutrophils: 510 nCPM
syncytiotrophoblasts: 268 nCPM
kupffer cells: 263 nCPM
oocytes: 244 nCPM

Immune cell

neutrophil: 145 nTPM
basophil: 76 nTPM
non-classical monocyte: 76 nTPM
plasmacytoid DC: 75 nTPM
intermediate monocyte: 73 nTPM
eosinophil: 65 nTPM

Brain region

hypothalamus: 69 nTPM
hippocampal formation: 66 nTPM
basal ganglia: 62 nTPM
cerebral cortex: 60 nTPM
white matter: 60 nTPM
spinal cord: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.3
DepMap mean gene effect: -1.01
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Akirin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKIRIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKIRIN2 as an antibody target. Whether an autoantibody or antibody against AKIRIN2 could matter depends on whether native AKIRIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKIRIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKIRIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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