Seroatlas · Human Serome Atlas

PSMB4

Proteasome subunit beta type-4

Also known as: HN3, PROS26, PSB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28070
Gene: PSMB4
Ensembl: ENSG00000159377
Chromosome: 1
Canonical length: 264 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>P28070|PSMB4
     1  MEAFLGSRSG LWAGGPAPGQ FYRIPSTPDS FMDPASALYR GPITRTQNPM VTGTSVLGVK
    61  FEGGVVIAAD MLGSYGSLAR FRNISRIMRV NNSTMLGASG DYADFQYLKQ VLGQMVIDEE
   121  LLGDGHSYSP RAIHSWLTRA MYSRRSKMNP LWNTMVIGGY ADGESFLGYV DMLGVAYEAP
   181  SLATGYGAYL AQPLLREVLE KQPVLSQTEA RDLVERCMRV LYYRDARSYN RFQIATVTEK
   241  GVEIEGPLST ETNWDIAHMI SGFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 303 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 303 nTPM
choroid plexus: 274 nTPM
liver: 269 nTPM
adrenal gland: 243 nTPM
heart muscle: 232 nTPM
blood vessel: 225 nTPM

Single-cell type

syncytiotrophoblasts: 322 nCPM
cytotrophoblasts: 251 nCPM
migrating cytotrophoblasts: 196 nCPM
extravillous trophoblasts: 170 nCPM
decidual stromal cells: 163 nCPM
gastric progenitor cells: 163 nCPM

Immune cell

plasmacytoid DC: 469 nTPM
myeloid DC: 422 nTPM
T-reg: 406 nTPM
total PBMC: 395 nTPM
NK-cell: 348 nTPM
classical monocyte: 344 nTPM

Brain region

white matter: 133 nTPM
hypothalamus: 122 nTPM
pons: 118 nTPM
spinal cord: 117 nTPM
cerebellum: 116 nTPM
medulla oblongata: 108 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMB4.

Disease | AllUniProt

Conditions PSMB4 is implicated in, by any mechanism.

Proteasome-associated autoinflammatory syndrome 3 (PRAAS3) MIM:617591

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 297 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Proteasome-associated autoinflammatory syndrome 3
Proteasome-associated autoinflammatory syndrome 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -2.21
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipopolysaccharide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proteasome, subunit alpha/beta
Proteasome beta-type subunit, conserved site
Proteasome B-type subunit
Nucleophile aminohydrolases, N-terminal
Proteasome subunit
Proteasome subunit beta 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB4 as an antibody target. Whether an autoantibody or antibody against PSMB4 could matter depends on whether native PSMB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...