Seroatlas · Human Serome Atlas

PSMB1

Proteasome subunit beta type-1

Also known as: HC5, PMSB1, PSB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20618
Gene
PSMB1
Ensembl
ENSG00000008018
Chromosome
6
Canonical length
241 aa
Protein class
Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>P20618|PSMB1
     1  MLSSTAMYSA PGRDLGMEPH RAAGPLQLRF SPYVFNGGTI LAIAGEDFAI VASDTRLSEG
    61  FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL KMYKHSNNKA MTTGAIAAML
   121  STILYSRRFF PYYVYNIIGG LDEEGKGAVY SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ
   181  VGFKNMQNVE HVPLSLDRAM RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK
   241  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
360 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 360 nTPM
  • liver: 288 nTPM
  • epididymis: 264 nTPM
  • choroid plexus: 239 nTPM
  • blood vessel: 237 nTPM
  • heart muscle: 224 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,445 nCPM
  • cytotrophoblasts: 1,014 nCPM
  • extravillous trophoblasts: 983 nCPM
  • migrating cytotrophoblasts: 914 nCPM
  • gastric progenitor cells: 692 nCPM
  • esophageal suprabasal cells: 576 nCPM

Immune cell

  • total PBMC: 653 nTPM
  • myeloid DC: 524 nTPM
  • T-reg: 444 nTPM
  • classical monocyte: 433 nTPM
  • intermediate monocyte: 417 nTPM
  • NK-cell: 409 nTPM

Brain region

  • white matter: 104 nTPM
  • hypothalamus: 95 nTPM
  • spinal cord: 92 nTPM
  • thalamus: 84 nTPM
  • pons: 84 nTPM
  • choroid plexus: 80 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMB1.

Disease | AllUniProt

Conditions PSMB1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with microcephaly, hypotonia, and absent language (NEDMHAL) MIM:620038

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 30 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with microcephaly, hypotonia, and absent language

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
0.87
DepMap mean gene effect
-1.73
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB1 as an antibody target. Whether an autoantibody or antibody against PSMB1 could matter depends on whether native PSMB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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