PSMA4
Proteasome subunit alpha type-4
Also known as: HC9, HsT17706, PSA4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P25789
- Gene
- PSMA4
- Ensembl
- ENSG00000041357
- Chromosome
- 15
- Canonical length
- 261 aa
- Protein class
- Enzymes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Cytosol,Connecting piece,Flagellar centriole,Mid piece
OverviewNCBI Gene
This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>P25789|PSMA4
1 MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF
61 FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA
121 YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK
181 EGEMTLKSAL ALAIKVLNKT MDVSKLSAEK VEIATLTREN GKTVIRVLKQ KEVEQLIKKH
241 EEEEAKAERE KKEKEQKEKD KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PSMA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 172 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 172 nTPM
- thymus: 146 nTPM
- liver: 144 nTPM
- lymph node: 128 nTPM
- tonsil: 120 nTPM
- esophagus: 114 nTPM
Single-cell type
- late primary spermatocytes: 722 nCPM
- early spermatids: 693 nCPM
- cytotrophoblasts: 556 nCPM
- migrating cytotrophoblasts: 539 nCPM
- extravillous trophoblasts: 536 nCPM
- syncytiotrophoblasts: 496 nCPM
Immune cell
- total PBMC: 406 nTPM
- intermediate monocyte: 404 nTPM
- non-classical monocyte: 397 nTPM
- myeloid DC: 328 nTPM
- classical monocyte: 252 nTPM
- T-reg: 218 nTPM
Brain region
- white matter: 44 nTPM
- spinal cord: 43 nTPM
- hypothalamus: 43 nTPM
- medulla oblongata: 39 nTPM
- pons: 39 nTPM
- cerebellum: 36 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.49
- gnomAD pLI
- 0.6
- gnomAD missense Z
- 2.44
- DepMap mean gene effect
- -1.56
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PSMA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PSMA4 as an antibody target. Whether an autoantibody or antibody against PSMA4 could matter depends on whether native PSMA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PSMA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PSMA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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