PSMD9

Protein identityUniProt · HPA

UniProt accession

O00233

Gene

PSMD9

Ensembl

ENSG00000110801

Chromosome

12

Canonical length

223 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>O00233|PSMD9
     1  MSDEEARQSG GSSQAGVVTV SDVQELMRRK EEIEAQIKAN YDVLESQKGI GMNEPLVDCE
    61  GYPRSDVDLY QVRTARHNII CLQNDHKAVM KQVEEALHQL HARDKEKQAR DMAEAHKEAM
   121  SRKLGQSESQ GPPRAFAKVN SISPGSPASI AGLQVDDEIV EFGSVNTQNF QSLHNIGSVV
   181  QHSEGKPLNV TVIRRGEKHQ LRLVPTRWAG KGLLGCNIIP LQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

17 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMD9.

Disease | ImmuneIEDB

Conditions an epitope on PSMD9 was assayed in.

• brain glioma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.45

gnomAD pLI

0

gnomAD missense Z

0.5

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of insulin secretion
• positive regulation of DNA-templated transcription
• positive regulation of insulin secretion
• proteasome regulatory particle assembly
• ubiquitin-dependent protein catabolic process

Molecular functions

• bHLH transcription factor binding
• transcription coactivator activity

Cellular components

• cytoplasm
• cytosol
• nucleus
• proteasome regulatory particle

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• PDZ superfamily
• PDZ domain 6
• PDZ domain
• 26S Proteasome non-ATPase regulatory subunit 9
• Nas2, N-terminal
• Nas2 N_terminal domain

KeywordsUniProt

• Chaperone
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PSMD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PSMC3
• CSH1
• PSMC4
• PSMC6
• PSMD12
• PSMD3
• PSMD6
• RAI14
• RPS14