Seroatlas · Human Serome Atlas

PSMB7

Proteasome subunit beta type-7

Also known as: PSB7_HUMAN, Z

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99436
Gene: PSMB7
Ensembl: ENSG00000136930
Chromosome: 9
Canonical length: 277 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Primary cilium,Cytosol

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q99436|PSMB7
     1  MAAVSVYAPP VGGFSFDNCR RNAVLEADFA KRGYKLPKVR KTGTTIAGVV YKDGIVLGAD
    61  TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ LISSNLELHS LSTGRLPRVV
   121  TANRMLKQML FRYQGYIGAA LVLGGVDVTG PHLYSIYPHG STDKLPYVTM GSGSLAAMAV
   181  FEDKFRPDME EEEAKNLVSE AIAAGIFNDL GSGSNIDLCV ISKNKLDFLR PYTVPNKKGT
   241  RLGRYRCEKG TTAVLTEKIT PLEIEVLEET VQTMDTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 266 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 266 nTPM
liver: 208 nTPM
heart muscle: 201 nTPM
tongue: 192 nTPM
bone marrow: 179 nTPM
adrenal gland: 171 nTPM

Single-cell type

late primary spermatocytes: 720 nCPM
late spermatids: 685 nCPM
syncytiotrophoblasts: 597 nCPM
oocytes: 585 nCPM
cytotrophoblasts: 552 nCPM
esophageal apical cells: 517 nCPM

Immune cell

total PBMC: 265 nTPM
T-reg: 227 nTPM
myeloid DC: 221 nTPM
intermediate monocyte: 212 nTPM
non-classical monocyte: 208 nTPM
classical monocyte: 202 nTPM

Brain region

midbrain: 133 nTPM
thalamus: 130 nTPM
pons: 130 nTPM
medulla oblongata: 128 nTPM
hypothalamus: 127 nTPM
basal ganglia: 122 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.89
gnomAD missense Z: 0.85
DepMap mean gene effect: -1.31
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB7 as an antibody target. Whether an autoantibody or antibody against PSMB7 could matter depends on whether native PSMB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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