Seroatlas · Human Serome Atlas

PSMD7

26S proteasome non-ATPase regulatory subunit 7

Also known as: MOV34, P40, PSMD7_HUMAN, Rpn8, S12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51665
Gene
PSMD7
Ensembl
ENSG00000103035
Chromosome
16
Canonical length
324 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Acrosome,Equatorial segment,Mid piece,Principal piece

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>P51665|PSMD7
     1  MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV SNSFAVPFDE
    61  DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK LHKNDIAINE LMKRYCPNSV
   121  LVIIDVKPKD LGLPTEAYIS VEEVHDDGTP TSKTFEHVTS EIGAEEAEEV GVEHLLRDIK
   181  DTTVGTLSQR ITNQVHGLKG LNSKLLDIRS YLEKVATGKL PINHQIIYQL QDVFNLLPDV
   241  SLQEFVKAFY LKTNDQMVVV YLASLIRSVV ALHNLINNKI ANRDAEKKEG QEKEESKKDR
   301  KEDKEKDKDK EKSDVKKEEK KEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
260 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 260 nTPM
  • tongue: 149 nTPM
  • heart muscle: 121 nTPM
  • bone marrow: 120 nTPM
  • esophagus: 85 nTPM
  • skin: 84 nTPM

Single-cell type

  • syncytiotrophoblasts: 819 nCPM
  • esophageal apical cells: 482 nCPM
  • cytotrophoblasts: 417 nCPM
  • migrating cytotrophoblasts: 376 nCPM
  • esophageal suprabasal cells: 373 nCPM
  • late primary spermatocytes: 333 nCPM

Immune cell

  • myeloid DC: 202 nTPM
  • eosinophil: 194 nTPM
  • non-classical monocyte: 189 nTPM
  • total PBMC: 188 nTPM
  • intermediate monocyte: 177 nTPM
  • plasmacytoid DC: 173 nTPM

Brain region

  • white matter: 52 nTPM
  • cerebral cortex: 51 nTPM
  • pons: 50 nTPM
  • thalamus: 49 nTPM
  • spinal cord: 49 nTPM
  • cerebellum: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.26
gnomAD missense Z
1.2
DepMap mean gene effect
-1.6
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD7 as an antibody target. Whether an autoantibody or antibody against PSMD7 could matter depends on whether native PSMD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD7 is annotated as secreted, so native PSMD7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSMD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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