Seroatlas · Human Serome Atlas

FKBP8

Peptidyl-prolyl cis-trans isomerase FKBP8

Also known as: FKBP38, FKBP8_HUMAN, FKBPr38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14318
Gene
FKBP8
Ensembl
ENSG00000105701
Chromosome
19
Canonical length
412 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Mitochondria,Cytosol
Quaternary structure
Homomultimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q14318|FKBP8
     1  MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS ELPPLEDMGQ
    61  PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG LLRKKTLVPG PPGSSRPVKG
   121  QVVTVHLQTS LENGTRVQEE PELVFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG
   181  PQGRSPYIPP HAALCLEVTL KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA
   241  ANSYDLAIKA ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE
   301  HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKHAAQRSTE
   361  TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FKBP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
594 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 594 nTPM
  • amygdala: 518 nTPM
  • basal ganglia: 515 nTPM
  • hippocampal formation: 489 nTPM
  • hypothalamus: 438 nTPM
  • midbrain: 382 nTPM

Single-cell type

  • late spermatids: 2,217 nCPM
  • esophageal apical cells: 1000 nCPM
  • platelets: 650 nCPM
  • esophageal suprabasal cells: 482 nCPM
  • late primary spermatocytes: 450 nCPM
  • erythrocytes: 445 nCPM

Immune cell

  • eosinophil: 94 nTPM
  • neutrophil: 79 nTPM
  • total PBMC: 30 nTPM
  • non-classical monocyte: 19 nTPM
  • basophil: 18 nTPM
  • memory CD8 T-cell: 16 nTPM

Brain region

  • cerebral cortex: 585 nTPM
  • white matter: 485 nTPM
  • medulla oblongata: 482 nTPM
  • amygdala: 481 nTPM
  • thalamus: 474 nTPM
  • basal ganglia: 452 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
2.33
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FKBP8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FKBP8 as an antibody target. Whether an autoantibody or antibody against FKBP8 could matter depends on whether native FKBP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FKBP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FKBP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FKBP8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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