Seroatlas · Human Serome Atlas

PSMD8

26S proteasome non-ATPase regulatory subunit 8

Also known as: HIP6, HYPF, Nin1p, p31, PSMD8_HUMAN, Rpn12, S14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48556
Gene
PSMD8
Ensembl
ENSG00000099341
Chromosome
19
Canonical length
350 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P48556|PSMD8
     1  MFIKGRAPRA PPRERRRATR GGLRQVVAPP RALGSTSRPH FRRASVCRRR CRKSGGLLAA
    61  SRKMAAAAVN GAAGFSSSGP AATSGAVLQA ATGMYEQLKG EWNRKSPNLS KCGEELGRLK
   121  LVLLELNFLP TTGTKLTKQQ LILARDILEI GAQWSILRKD IPSFERYMAQ LKCYYFDYKE
   181  QLPESAYMHQ LLGLNLLFLL SQNRVAEFHT ELERLPAKDI QTNVYIKHPV SLEQYLMEGS
   241  YNKVFLAKGN IPAESYTFFI DILLDTIRDE IAGCIEKAYE KILFTEATRI LFFNTPKKMT
   301  DYAKKRGWVL GPNNYYSFAS QQQKPEDTTI PSTELAKQVI EYARQLEMIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
667 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 667 nTPM
  • heart muscle: 341 nTPM
  • tongue: 331 nTPM
  • adipose tissue: 209 nTPM
  • breast: 176 nTPM
  • skin: 168 nTPM

Single-cell type

  • late spermatids: 1,825 nCPM
  • syncytiotrophoblasts: 666 nCPM
  • late primary spermatocytes: 646 nCPM
  • esophageal apical cells: 644 nCPM
  • esophageal suprabasal cells: 516 nCPM
  • esophageal basal cells: 436 nCPM

Immune cell

  • total PBMC: 350 nTPM
  • non-classical monocyte: 319 nTPM
  • T-reg: 292 nTPM
  • intermediate monocyte: 263 nTPM
  • myeloid DC: 261 nTPM
  • classical monocyte: 237 nTPM

Brain region

  • pons: 143 nTPM
  • hypothalamus: 135 nTPM
  • white matter: 125 nTPM
  • cerebral cortex: 123 nTPM
  • thalamus: 122 nTPM
  • hippocampal formation: 118 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.07
gnomAD missense Z
0.48
DepMap mean gene effect
-0.9
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD8 as an antibody target. Whether an autoantibody or antibody against PSMD8 could matter depends on whether native PSMD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMD8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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