Seroatlas · Human Serome Atlas

ADRM1

Proteasomal ubiquitin receptor ADRM1

Also known as: ADRM1_HUMAN, ARM1, GP110, PSMD16, Rpn13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16186
Gene: ADRM1
Ensembl: ENSG00000130706
Chromosome: 20
Canonical length: 407 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q16186|ADRM1
     1  MTTSGALFPS LVPGSRGASN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC
    61  WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH
   121  CRKVNEYLNN PPMPGALGAS GSSGHELSAL GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL
   181  GGLGALTGPG LASLLGSSGP PGSSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASAT
   241  SPSPAPSSGN GASTAASPTQ PIQLSDLQSI LATMNVPAGP AGGQQVDLAS VLTPEIMAPI
   301  LANADVQERL LPYLPSGESL PQTADEIQNT LTSPQFQQAL GMFSAALASG QLGPLMCQFG
   361  LPAEAVEAAN KGDVEAFAKA MQNNAKPEQK EGDTKDKKDE EEDMSLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADRM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 376 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 376 nTPM
testis: 130 nTPM
liver: 121 nTPM
heart muscle: 111 nTPM
esophagus: 102 nTPM
skin: 96 nTPM

Single-cell type

late spermatids: 2,560 nCPM
syncytiotrophoblasts: 525 nCPM
esophageal apical cells: 417 nCPM
early spermatids: 376 nCPM
cytotrophoblasts: 282 nCPM
esophageal basal cells: 248 nCPM

Immune cell

naive B-cell: 267 nTPM
T-reg: 267 nTPM
intermediate monocyte: 262 nTPM
memory B-cell: 261 nTPM
total PBMC: 261 nTPM
eosinophil: 234 nTPM

Brain region

medulla oblongata: 76 nTPM
pons: 74 nTPM
hypothalamus: 69 nTPM
cerebellum: 68 nTPM
cerebral cortex: 67 nTPM
thalamus: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DEUBAD domain
Proteasomal ubiquitin receptor Rpn13/ADRM1
RPN13, DEUBAD domain
RPN13, DEUBAD domain superfamily
Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily
Rpn13/ADRM1, Pru domain
Proteasome complex subunit Rpn13, Pru domain
UCH-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADRM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADRM1 as an antibody target. Whether an autoantibody or antibody against ADRM1 could matter depends on whether native ADRM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADRM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADRM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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