Seroatlas · Human Serome Atlas

PSMA6

Proteasome subunit alpha type-6

Also known as: IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27, PSA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60900
Gene
PSMA6
Ensembl
ENSG00000100902
Chromosome
14
Canonical length
246 aa
Protein class
Enzymes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Primary cilium tip,Cytosol,Perinuclear theca,Calyx,Connecting piece,Flagellar centriole,Mid piece,End piece

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>P60900|PSMA6
     1  MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL
    61  LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD
   121  ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE
   181  KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV
   241  ALAERD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
333 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 333 nTPM
  • thymus: 270 nTPM
  • testis: 235 nTPM
  • tongue: 191 nTPM
  • liver: 161 nTPM
  • heart muscle: 159 nTPM

Single-cell type

  • other brain neurons: 57 nCPM
  • brain excitatory neurons: 49 nCPM
  • brain inhibitory neurons: 48 nCPM
  • oligodendrocytes: 47 nCPM
  • choroid plexus epithelial cells: 46 nCPM
  • microglia: 45 nCPM

Immune cell

  • total PBMC: 712 nTPM
  • plasmacytoid DC: 386 nTPM
  • myeloid DC: 374 nTPM
  • classical monocyte: 366 nTPM
  • non-classical monocyte: 345 nTPM
  • intermediate monocyte: 345 nTPM

Brain region

  • hypothalamus: 69 nTPM
  • pons: 66 nTPM
  • thalamus: 60 nTPM
  • medulla oblongata: 60 nTPM
  • cerebral cortex: 59 nTPM
  • spinal cord: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
2.41
DepMap mean gene effect
-2.8
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMA6 as an antibody target. Whether an autoantibody or antibody against PSMA6 could matter depends on whether native PSMA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...