C1-like domain superfamily
IPR046349
Definition
This superfamily includes variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc PMID:1396661. This superfamily also includes the C-terminal domain of General transcription factor IIH subunit 2 whose structure revealed homology with the regulatory domain of protein kinase C PMID:10882739.
60 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (60 proteins: gene, accession, name)
- AKAP13
- ARAF
- ARHGAP29
- ARHGAP45
- ARHGEF2
- ARHGEF28
- BRAF
- CDC42BPA
- CDC42BPB
- CDC42BPG
- CHN1
- CHN2
- CIT
- DEF8
- DGKA
- DGKB
- DGKD
- DGKE
- DGKG
- DGKH
- DGKK
- DGKQ
- GMIP
- GTF2H2
- GTF2H2C
- KSR1
- KSR2
- MYO9A
- MYO9B
- PDZD8
- PRKCA
- PRKCB
- PRKCD
- PRKCE
- PRKCG
- PRKCH
- PRKCI
- PRKCQ
- PRKCZ
- PRKD1
- PRKD2
- PRKD3
- RACGAP1
- RAF1
- RASGRP1
- RASGRP2
- RASGRP3
- RASGRP4
- RASSF1
- RASSF5
- ROCK1
- ROCK2
- STAC
- STAC2
- STAC3
- TNS1
- TNS2
- UNC13A
- UNC13B
- UNC13C
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