CHN2

Protein identityUniProt · HPA

UniProt accession

P52757

Gene

CHN2

Ensembl

ENSG00000106069

Chromosome

7

Canonical length

468 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>P52757|CHN2
     1  MAASSNSSLS GSSVSSDAEE YQPPIWKSYL YQLQQEAPRP KRIICPREVE NRPKYYGREF
    61  HGIISREQAD ELLGGVEGAY ILRESQRQPG CYTLALRFGN QTLNYRLFHD GKHFVGEKRF
   121  ESIHDLVTDG LITLYIETKA AEYISKMTTN PIYEHIGYAT LLREKVSRRL SRSKNEPRKT
   181  NVTHEEHTAV EKISSLVRRA ALTHNDNHFN YEKTHNFKVH TFRGPHWCEY CANFMWGLIA
   241  QGVRCSDCGL NVHKQCSKHV PNDCQPDLKR IKKVYCCDLT TLVKAHNTQR PMVVDICIRE
   301  IEARGLKSEG LYRVSGFTEH IEDVKMAFDR DGEKADISAN VYPDINIITG ALKLYFRDLP
   361  IPVITYDTYS KFIDAAKISN ADERLEAVHE VLMLLPPAHY ETLRYLMIHL KKVTMNEKDN
   421  FMNAENLGIV FGPTLMRPPE DSTLTTLHDM RYQKLIVQIL IENEDVLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

171 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0

gnomAD missense Z

1.13

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acrosome assembly
• regulation of small GTPase mediated signal transduction
• signal transduction

Molecular functions

• GTPase activator activity
• zinc ion binding

Cellular components

• cytosol
• membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• Rho GTPase-activating protein domain
• SH2 domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Rho GTPase activation protein
• Chimaerin
• Diacylglycerol/phorbol-ester binding
• Chimaerin, SH2 domain
• SH2 domain superfamily
• Chimaerin, RhoGAP domain
• C1-like domain superfamily
• Rho-type GTPase-activating protein
• SH2 domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• RhoGAP domain

KeywordsUniProt

• GTPase activation
• Membrane
• Metal-binding
• SH2 domain
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of CHN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NCK1
• RAC1