Seroatlas · Human Serome Atlas

KSR1

Kinase suppressor of Ras 1

Also known as: KSR, KSR1_HUMAN, RSU2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVT5
Gene
KSR1
Ensembl
ENSG00000141068
Chromosome
17
Canonical length
923 aa
Protein class
Enzymes, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

923 residues, UniProt reviewed canonical sequence.

>Q8IVT5|KSR1
     1  MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
    61  KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
   121  EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
   181  SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
   241  PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
   301  PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
   361  HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
   421  PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
   481  QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
   541  DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
   601  VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
   661  YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
   721  MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
   781  PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
   841  RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
   901  SSKVVPRFER FGLGVLESSN PKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 104 nTPM
  • kidney: 45 nTPM
  • placenta: 42 nTPM
  • cervix: 36 nTPM
  • thyroid gland: 32 nTPM
  • esophagus: 31 nTPM

Single-cell type

  • cone photoreceptor cells: 271 nCPM
  • respiratory secretory cells: 227 nCPM
  • pancreatic acinar cells: 198 nCPM
  • retinal pigment epithelial cells: 175 nCPM
  • respiratory ciliated cells: 154 nCPM
  • endometrial luminal cells: 149 nCPM

Immune cell

  • eosinophil: 3.9 nTPM
  • intermediate monocyte: 2.1 nTPM
  • neutrophil: 1.1 nTPM
  • non-classical monocyte: 1.1 nTPM
  • classical monocyte: 1 nTPM
  • NK-cell: 0.9 nTPM

Brain region

  • cerebral cortex: 74 nTPM
  • hippocampal formation: 70 nTPM
  • medulla oblongata: 61 nTPM
  • white matter: 54 nTPM
  • pons: 49 nTPM
  • thalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.07
gnomAD missense Z
2
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KSR1 as an antibody target. Whether an autoantibody or antibody against KSR1 could matter depends on whether native KSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KSR1 is annotated at the cell surface, where native KSR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KSR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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